Publications

Summary of ceftaroline activity against pathogens in the United States, 2010: Report from the Assessing Worldwide Antimicrobial Resistance Evaluation (AWARE) Surveillance Program. by Flamm RK, Sader HS, Farrell DJ and Jones RN published in Antimicrob. Agents Chemother. 2012; 56 (6): 2933-2940

Antifungal drug resistance: Mechanisms, epidemiology, and consequences for treatment. by Pfaller MA published in Am. J. Med. 2012; 125 (1 Suppl): S3-S13

Oritavancin activity against vancomycin-susceptible and vancomycin-resistant enterococci with molecularly characterized glycopeptide resistance genes recovered from bacteremic patients, 2009-2010. by Mendes RE, Woosley LN, Farrell DJ, Sader HS and Jones RN published in Antimicrob. Agents Chemother. 2012; 56 (3): 1639-1642

Telavancin activity tested against a contemporary collection of Gram-positive pathogens from USA hospitals (2007-2009). by Mendes RE, Sader HS, Farrell DJ and Jones RN published in Diagn. Microbiol. Infect. Dis. 2012; 72 (1): 113-117

Pharmacodynamics of beta-lactamase inhibition by NXL104 in combination with ceftaroline, examining organisms with multiple types of beta-lactamases. by Louie A, Castanheira M, Liu W, Grasso C, Jones RN, Williams G, Critchley I, Thye D, Brown D, Vanscoy B, Kulawy R and Drusano GL published in Antimicrob. Agents Chemother. 2012; 56 (1): 258-270

Synergistic activity of ceftobiprole and vancomycin in a rat model of infective endocarditis caused by methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus. by Fernandez J, Abbanat D, Shang W, He W, Amsler K, Hastings J, Queenan AM, Melton JL, Barron AM, Flamm RK and Lynch AS published in Antimicrob. Agents Chemother. 2012; 56 (3): 1476-1484

Expansion of clonal complex 258 KPC-2-producing Klebsiella pneumoniae in Latin American hospitals: Report of the SENTRY antimicrobial surveillance program. by Castanheira M, Costello AJ, Deshpande LM and Jones RN published in Antimicrob. Agents Chemother. 2012; 56 (3): 1668-1669

Evaluation of quinolone resistance-determining region mutations and efflux pump expression in Neisseria meningitidis resistant to fluoroquinolones. by Castanheira M, Deshpande LM, Jones RN and Farrell DJ published in Diagn. Microbiol. Infect. Dis. 2012; 72 (3): 263-266

Activities of E1210 and comparator agents tested by CLSI and EUCAST broth microdilution methods against Fusarium and Scedosporium species identified using molecular methods. by Castanheira M, Duncanson FP, Diekema DJ, Guarro J, Jones RN and Pfaller MA published in Antimicrob. Agents Chemother. 2012; 56 (1): 352-357

Antimicrobial activity of the investigational pleuromutilin compound BC-3781 tested against gram-positive organisms commonly associated with acute bacterial skin and skin structure infections. by Sader HS, Biedenbach DJ, Paukner S, Ivezic-Schoenfeld Z, Jones RN published in Antimicrob. Agents Chemother. 2012; 56 (3): 1619-1623

Activity of ceftobiprole against Streptococcus pneumoniae isolates exhibiting high-level resistance to ceftriaxone. by Davies TA, Flamm RK and Lynch AS published in Int. J. Antimicrob. Agents. 2012; 39 (6): 534-538

Activity of JNJ-Q2, a new fluoroquinolone, tested against contemporary pathogens isolated from patients with community-acquired bacterial pneumonia. by Biedenbach DJ, Farrell DJ, Flamm RK, Liverman LC, McIntyre G and Jones RN published in Int. J. Antimicrob. Agents. 2012; 39 (4): 321-325

Unmet needs and prospects for oritavancin in the management of vancomycin-resistant enterococcal infections. by Arias CA, Mendes RE, Stilwell MG, Jones RN and Murray BE published in Clin. Infect. Dis. 2012; 54 (Suppl 3): S233-S238

Antimicrobial activity of the novel pleuromutilin antibiotic BC-3781 against organisms responsible for community-acquired respiratory tract infections (CARTIs). by Sader HS, Paukner S, Ivezic-Schoenfeld Z, Biedenbach DJ, Schmitz FJ and Jones RN published in J. Antimicrob. Chemother. 2012; 67 (5): 1170-1175

Antimicrobial activity of daptomycin in comparison to glycopeptides and other antimicrobials when tested against numerous species of coagulase-negative Staphylococcus. by Sader HS and Jones RN published in Diagn. Microbiol. Infect. Dis. 2012; 73 (2): 212-214

Wild-type MIC distributions and epidemiological cutoff values for amphotericin B, flucytosine, and itraconazole and Candida spp. as determined by CLSI broth microdilution. by Pfaller MA, Espinel-Ingroff A, Castanheira M, Cuenca-Estrella M, Diekema DJ, Fothergill A, Faller J, Ghannoum M, Jones RN, Lockhart SR, Ostrosky-Zeichner L and Pelaez T published in J. Clin. Microbiol. 2012; 50 (6): 2040-2046

Frequency of decreased susceptibility and resistance to echinocandins among fluconazole-resistant bloodstream isolates of Candida glabrata. by Pfaller MA, Castanheira M, Lockhart SR, Ahlquist AM, Messer SA and Jones RN published in J. Clin. Microbiol. 2012; 50 (4): 1199-1203

Molecular evaluation of mupirocin resistances among Staphylococcus aureus collect in United States (USA) during 2008-2010, Lead author: Castanheira M, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Trends in Klebsiella pneumoniae carbapenemase positive (KPC+) K. pneumoniae in USA Hospitals: Report from the 2007-2009 from the SENTRY Antimicrobial Surveillance Program, Lead author: Kaise, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Antimicrobial Activity of Ceftaroline Tested Against Bacteria Collected from Patients with Respiratory Tract Infections in the United States (2010), Lead author: Sader HS, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Do CLSI breakpoints Predict Presence of Klebsiella pneumoniae Carbapenamase (KPC) Gene among USA Enterobacteriaceae isolates?, Lead author: Kaise, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Eight broad spectrum &#223-lactam agents tested against a large collection of KPC-producing Enterobacteriaceae: Evaluation of current CLSI breakpoints, Lead author: Castanheira M, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Antimicrobial Activity of Ceftaroline/NXL104 Tested Against Contemporary (2010) Clinical Isolates from USA Medical Centers, Lead author: Sader HS, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Antimicrobial Activity and Spectrum of the Novel Cephalosporin Ceftaroline Tested Against Bacterial Isolates Causing Skin and Skin Structure Infections in USA Medical Centers, Lead author: Sader HS, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Activity of JNJ-Q2 and Comparators against Genetically Defined MRSA Clones, Lead author: Farrell DJ, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Evaluation of Occurrence and Resistance Mechanisms of Pleuromutilins in Staphylococcus aureus Clinical Isolates: Report from the SENTRY Antimicrobial Surveillance Program, Lead author: Mendes RE, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Activity of JNJ-Q2, a Novel Fluoroquinolone, Tested against Neisseria gonorrhoeae, Including Ciprofloxacin-Resistant Strains, Lead author: Farrell DJ, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Wild-Type MIC Distributions and Epidemiological Cutoff Values for Fluconazole, Posaconazole and Voriconazole versus Cryptococcus neoformans as Determined by 72 hour CLSI Broth Microdilution Method, Lead author: Pfaller MA, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Wild-Type (WT) MIC Distributions and Epidemiological Cutoff Values (ECVs) for Selected Triazole and Echinocandin Antifungal Agents for Six Uncommon Species of Candida as Determined by CLSI Broth Microdilution (BMD) Methods, Lead author: Pfaller MA, presented at 49th annual Infectious Diseases Society of America (IDSA), October 20 – 23, 2011, Boston, MA

Pharmacokinetic/Pharmacodynamic (PK/PD) Evaluations in Support of In Vitro Interpretive Criteria for Fluoroquinolones Against Salmonella and Enterobacteriaceae, Lead author: Bhavnani SM, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Differential &#223-Lactam Susceptibility Between Hospital and Community-Associated Clonal Complexes of Methicillin-Resistant Staphylococcus aureus from Australia and New Zealand (2009-2010), Lead author: Bell JM, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Antimicrobial Activity of Ceftazidime/NXL104 (CAZ104) Tested Against Gram-Negative Organisms Causing Infections in Medical Centers from Europe, Latin America and the Asia-Pacific Region, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Oritavancin Activity against Vancomycin-susceptible and Genetically Characterized Vancomycin-resistant Enterococci from Bacteremic Patients (2009 – 2010), Lead author: Mendes RE, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Activity of Ceftaroline Combined with NXL104 Tested Against Bacterial Isolates from Patients with Respiratory Tract Infections from United States Medical Centers, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

In Vitro Activity of Ceftaroline Tested against Bacterial Pathogens Frequently Isolated in United States Medical Centers: Results from the AWARE Surveillance Program, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Update on Telavancin Activity Tested Against a Global Collection of Gram-positive Pathogens (2010), Lead author: Mendes RE, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Antimicrobial Activity of BC-3781, an Investigational Pleuromutilin, Tested Against Organisms Isolated From Patients with Community-Acquired Respiratory Tract Infections, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Analysis of the Molecular Epidemiology of Staphylococcus epidermidis Clinical Isolates from USA Hospitals, Lead author: Mendes RE, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Occurrence of NDM-1 and other carbapenemases among Acinetobacter spp. and Pseudomonas spp. Collected from India, Lead author: Castanheira M, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

A Multi-Site Evaluation to Determine the Performance of the Sensititre YeastOne Susceptibility System using the Sensititre Vizion Compared to a Mirror Read Method, Lead author: Holliday, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Potency of Dalbavancin Tested Against 37,258 Gram-positive Cutaneous Pathogens from USA Medical Centers (2006-2009), Lead author: Jones RN, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Antimicrobial Activity of Daptomycin in Comparison to Glycopeptides and Other Antimicrobials When Tested against Numerous Species of Coagulase-negative Staphylococcus (CoNS), Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

In Vitro Activity of Ceftazidime/NXL104 Against Pathogens Collected During a Phase II Complicated Urinary Tract infection (cUTI) Clinical Trial, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Activity of AFN-1252, a FabI Inhibitor with Potent Activity against S. aureus and Coagulase-Negative Staphylococcus spp. (CoNS), Including Multidrug-Resistant Strains, Lead author: Biedenbach DJ, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Antimicrobial Activity of Four Oxazolidinone Investigational Compounds Tested against a Collection of Linezolid-non-susceptible Strains with Genetically Defined Resistance Mechanisms, Lead author: Sader HS, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

In vitro Activity of a Novel Broad-spectrum Antifungal Agent, E1210, and Comparators Tested against Candida spp., Lead author: Castanheira M, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Pre-clinical Development of Susceptibility Testing Methods for the Novel Antifungal E1210 Tested against Candida: Comparison of CLSI and EUCAST Methods, Lead author: Castanheira M, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

In vitro Activity of a Novel Broad-spectrum Antifungal, E1210, Tested against Aspergillus spp. By CLSI and EUCAST Broth Microdilution Methods, Lead author: Castanheira M, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Profile of Staphylococcus aureus Isolated from United States (USA) Pediatric Patients During the 2009 Ceftaroline AWARE Surveillance Program, Lead author: Krause, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL

Evaluation of Pneumococci Isolated from United States (USA) Pediatric Patients During the 2009 AWARE Program, Lead author: Krause, presented at 51st annual Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), September 17 – 20, 2011, Chicago, IL